Cov kws tshawb fawb los ntawm Hiroshima University tau tshawb pom qhov sib xyaw tshiab hauv broccoli thiab lwm yam brassicas uas tuaj yeem pab tua qee yam mob qog noj ntshav.
DIM, los yog 3,3'-diindolylmethane, ua rau tswj cell tuag thiab rov ua dua ntawm cov khoom siv cellular hauv fission poov xab. Seb lub tshuab ntawm kev puas tsuaj los ntawm DIM tau txais kev cawmdim hauv tib neeg tam sim no tsis paub.
Ueno, tus pab xibfwb ntawm Hiroshima Healthy Aging Research Center ntawm Graduate School of Integrated Life Sciences ntawm Hiroshima University tau hais tias "Peb pom tias cov tshuaj sib xyaw DIM ua rau muaj kev ua haujlwm lom neeg tshiab uas ua rau cov ntaub so ntswg puas tsuaj hauv cov poov xab.
Ueno hais tias "Kev ncaj ncees ntawm daim nyias nyias yog qhov tseem ceeb rau tib neeg kev noj qab haus huv," Ueno hais. “Kev hloov pauv uas ua rau muaj qhov tsis xws luag hauv daim nyias nyias nyias ua kom muaj kev laus. Nuclear daim nyias nyias kuj ruptured thiab kho thaum lub sij hawm mob qog noj ntshav. "
Ib feem ntawm cov txheej txheem kho ntawm tes yog hu ua autophagy lossis "kev noj tus kheej." Qhov no yog ib txoj hauv kev ntawm degradation ntawm cellular Cheebtsam, nyob rau hauv uas lub cell yuav siv nws sab hauv lub cev kom txuag tau lub zog thiab optimize cov txheej txheem tseem ceeb.
Ueno kuj tau sau tseg tias autophagy cuam tshuam nrog ob qho tib si kev laus thiab cov kab mob muaj hnub nyoog. Yog tias lub xovtooj tsis zoo, nws tuag los ntawm txoj kev tuag hu ua apoptosis. Ntau cov tshuaj cytotoxic anticancer ua haujlwm los ntawm inducing apoptosis, yog li muaj peev xwm tswj tau cov txheej txheem no tuaj yeem pab tswj thiab txhim kho tib neeg kev noj qab haus huv, Ueno tau hais.
"Peb cov txiaj ntsig tau qhia tias lub hnab ntawv nuclear yuav yog ib qho ntawm thawj lub hom phiaj ntawm DIM," hais tias tus kws sau ntawv Parvaneh Emami, tus kawm tiav ntawm Tsev Kawm Ntawv Qib Siab Kev Tshawb Fawb Txog Kev Ua Neej ntawm Hiroshima University.
Qhov kev tshawb pom no tau tsim los ntawm tsab ntawv tshaj tawm dhau los los ntawm pab pawg tshawb fawb hauv tebchaws Yelemes uas pom tias muaj DIM siab ntau ntxiv rau lub neej ntawm fission poov xab.
Tej zaum nws yuav zoo li tsis txaus ntseeg tias qhov sib xyaw apoptosis-inducing tuaj yeem ua rau lub cev muaj sia nyob, tab sis Emami piav qhia tias DIM tsuas yog tshwm sim los ntxias tus cwj pwm no hauv kev faib cov hlwb, xws li cov qog nqaij hlav cancer. Yog tias lawv tuag, cov kab mob tuaj yeem nyob ntev dua.
"Kev tshawb fawb tsis ntev los no hauv tib neeg qhia tias DIM yog cov tshuaj tiv thaiv kab mob qog noj ntshav uas ua los ntawm kev ua kom apoptosis hauv ntau hom mob qog noj ntshav, suav nrog lub mis, prostate, gastric thiab pancreatic cancer," Ueno tau hais.
"Kev tshawb fawb tseem qhia tau tias DIM induces autophagy hauv cov qog nqaij hlav cancer. Txawm li cas los xij, cov nyhuv ntawm autophagy ntawm cov qog tsim thiab kev loj hlob tsis tau nkag siab tag nrho. Nkag siab txog cov txheej txheem ntawm apoptosis thiab autophagy los ntawm DIM hauv fission poov xab yuav pab tau rau kev tshawb fawb rau tib neeg mob qog noj ntshav thiab cov txheej txheem ntawm kev ua neej ntev. "
Cov kws tshawb fawb tseem yuav kawm ntxiv txog lub luag haujlwm ntawm DIM hauv fission poov xab.
Emami tau hais tias "Peb xav nkag siab yuav ua li cas DIM ua rau muaj kev puas tsuaj rau fission poov xab nuclear membranes, uas tuaj yeem ua rau kev txhim kho cov tshuaj thawj zaug hauv chav kawm los tua cov qog nqaij hlav cancer," Emami hais.
"Peb kuj xav nkag siab txog cov txheej txheem ntawm yuav ua li cas DIM induces autophagy nyob rau hauv fission poov xab, uas yuav pab tau kom nkag siab txog yuav ua li cas mus cuag tib neeg lifespan."